Characterization of a methyltransferase involved in herboxidiene biosynthesis.

doi:10.1016/j.bmcl.2013.08.023

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Article

Characterization of a methyltransferase involved in herboxidiene biosynthesis.

Bioorganic & medicinal chemistry letters - 15 Oct 2013

Yu Dayu, Xu Fuchao, Zhang Shuwei, Shao Lei, Wang Siyuan, Zhan Jixun

Abstract excerpt

The herboxidiene biosynthetic gene cluster contains a regulatory gene and six biosynthetic genes that encode three polyketide synthases (HerB, HerC and HerD) and three tailoring enzymes (HerE, HerF and HerG). Through single crossover recombination, an integrative plasmid was inserted into the genome of Streptomyces chromofuscus ATCC 49982 between herE and herF, resulting in low-level expression of herF and the...

Topics

Bacterial Proteins
Escherichia coli
Fatty Alcohols
Genome, Bacterial
Kinetics
Magnetic Resonance Spectroscopy
Methyltransferases
Molecular Conformation
Multigene Family
Mutation
Polyketide Synthases
Pyrans
Streptomyces

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Open in PubMed

Identifiers

PMID: 23992865
DOI: 10.1016/j.bmcl.2013.08.023

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