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Article

Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.

Journal of the American Chemical Society - 19 May 2010

Luo Yinggang, Li Wenli, Ju Jianhua, Yuan Qiuping, Peters Noel R, Hoffmann F Michael, Huang Sheng-Xiong, Bugni Tim S, Rajski Scott, Osada Hiroyuki, Shen Ben

Abstract excerpt

The biosynthetic gene cluster for tautomycetin (TTN), a highly potent and selective protein phosphatase (PP) inhibitor isolated from Streptomyces griseochromogenes, has recently been cloned and sequenced. To better understand the transformations responsible for converting the post-polyketide synthase product into the exciting anticancer and immunosuppressive chemotherapeutic candidate TTN, we produced and...

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Source

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Identifiers

PMID: 20426415
DOI: 10.1021/ja9082446
PMCID: PMC2876980

Genes

TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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