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Article

K-ras gene mutation status in colorectal cancer: comparative analysis of pyrosequencing and PCR-RFLP.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie - 1 Jan 2013

Dobre Maria, Comănescu Maria, Arsene D, Iosif Cristina, Bussolati G

Abstract excerpt

BACKGROUND: In patients with high-stage colorectal carcinomas (CRC), anti-EGFR therapy is known to be effective only in cases with a wild-type K-ras gene status. Different procedures have been proposed for such evaluation. MATERIALS AND METHODS: The mutation status of K-ras gene, codons 12, 13 and 61 was determined in 250 CRC cases using the pyrosequencing assay. In addition, we compared the performance of the...

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PMID: 24068405

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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