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Article

The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.

Molecular cell - 10 Oct 2008

Sun Weili, Nandi Saikat, Osman Fekret, Ahn Jong Sook, Jakovleska Jovana, Lorenz Alexander, Whitby Matthew C

Abstract excerpt

The Fanconi anemia (FA) core complex promotes the tolerance/repair of DNA damage at stalled replication forks by catalyzing the monoubiquitination of FANCD2 and FANCI. Intriguingly, the core complex component FANCM also catalyzes branch migration of model Holliday junctions and replication forks in vitro. Here we have characterized the ortholog of FANCM in fission yeast Fml1 in order to understand the...

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Share to Crossing Over, Genetic
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Replication

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Source

Open in PubMed Open full text

Identifiers

PMID: 18851838
DOI: 10.1016/j.molcel.2008.08.024
PMCID: PMC2581491

Genes

FANCM
FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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