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Article

Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.

Cell cycle (Georgetown, Tex.) - 1 Jul 2012

Lee Kwanwoo, Rhee Kunsoo

Abstract excerpt

Centriole disengagement is considered an essential step for licensing a new round of centriole duplication in the next cell cycle. Separase is critical for centriole disengagement. Here, we showed that pericentrin B (PCNTB) is specifically cleaved by separase at the exit of mitosis. The cleavage-resistant PCNTB mutant blocks the centriole disengagement and duplication. We also observed that an artificial cleavage...

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Identifiers

PMID: 22722493
DOI: 10.4161/cc.20878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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