Article

CDC20B is required for deuterosome-mediated centriole production in multiciliated cells

2017-11-13

Abstract excerpt

Multiciliated cells (MCCs) harbour dozens to hundreds of motile cilia, which beat in a synchronized and directional manner, thus generating hydrodynamic forces important in animal physiology. In vertebrates, MCC differentiation critically depends on the synthesis and release of numerous centrioles by specialized structures called deuterosomes. Little is known about the composition, organization and regulation of d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78d7fe70-5350-58d7-a33b-b6da327a9271
DOI: 10.1101/218750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDC20B is required for deuterosome-mediated centriole production in multiciliated cellsDOI 10.1101/218750Read

Deciphering the dynamic proteome of multiciliated cellsSemantic proximity Read

Multicilin drives centriole biogenesis via E2f proteins.Semantic proximity Read

A ciliopathy complex builds distal appendages to initiate ciliogenesisSemantic proximity Read

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesisSemantic proximity Read

The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potentialSemantic proximity Read

DDX24, a D-E-A-D box RNA helicase, is required for muscle fiber organization and anterior pole specification essential for head regeneration in planariansSemantic proximity Read

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiationSemantic proximity Read

The Chromatin Remodeling Protein CHD-1 and the EFL-1/DPL-1 Transcription Factor Cooperatively Down Regulate CDK-2 to Control SAS-6 Levels and Centriole NumberSemantic proximity Read

Cyclin-dependent kinase control of motile ciliogenesis.Semantic proximity Read

<i>DONSON</i> , a gene responsible for microcephalic primordial dwarfism, ensures proper centriole duplication cycle by maintaining centriole engagement during interphaseSemantic proximity Read

Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.Semantic proximity Read

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.Semantic proximity Read