Article
Klp10A, a microtubule-depolymerizing kinesin-13, cooperates with CP110 to control Drosophila centriole length.
Current biology : CB - 20 Mar 2012
Delgehyr Nathalie, Rangone Hélène, Fu Jingyan, Mao Guojie, Tom Brian, Riparbelli Maria Giovanna, Callaini Giuliano, Glover David M
Abstract excerpt
Klp10A is a kinesin-13 of Drosophila melanogaster that depolymerizes cytoplasmic microtubules. In interphase, it promotes microtubule catastrophe; in mitosis, it contributes to anaphase chromosome movement by enabling tubulin flux. Here we show that Klp10A also acts as a microtubule depolymerase on centriolar microtubules to regulate centriole length. Thus, in both cultured cell lines and the testes, absence of...
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