Article
Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.
The EMBO journal - 6 Jan 2010
Fong Chii Shyang, Sato Masamitsu, Toda Takashi
Abstract excerpt
The centrosomal pericentrin-related proteins play pivotal roles in various aspects of cell division; however their underlying mechanisms remain largely elusive. Here we show that fission-yeast pericentrin-like Pcp1 regulates multiple functions of the spindle pole body (SPB) through recruiting two critical factors, the gamma-tubulin complex (gamma-TuC) and polo kinase (Plo1). We isolated two pcp1 mutants (pcp1-15...
Topics
- Cell Cycle Proteins
- Centrosome
- Genes, Fungal
- Interphase
- Microscopy, Electron, Transmission
- Mitosis
- Models, Biological
- Multiprotein Complexes
- Mutation
- Nuclear Envelope
- Nuclear Proteins
- Protein Serine-Threonine Kinases
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Spindle Apparatus
- Tubulin