Article

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

2022-09-30

Abstract excerpt

A tight synchrony between the DNA and centrosome cycle is essential for genomic integrity. Centriole disengagement, which licenses centrosomes for duplication, occurs normally during mitotic exit. We recently demonstrated that mild DNA replication stress in untransformed human cells causes premature centriole disengagement at mitotic entry, leading to transient multipolar spindles that favour chromosome mis-segreg...

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Literature Corpus work: e5a56a85-5b7d-534b-b1c3-2370cd3c11f2
DOI: 10.1101/2022.09.29.510042

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