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Article

Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia.

Journal of translational medicine - 25 Oct 2022

Polli Andrea, Hendrix Jolien, Ickmans Kelly, Bakusic Jelena, Ghosh Manosij, Monteyne Dora, Velkeniers Brigitte, Bekaert Bram, Nijs Jo, Godderis Lode

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening. COMT regulates nociceptive processing and inflammation, key pathophysiological features of Chronic Fatigue Syndrome and Fibromyalgia (CFS/FM). We aimed to determine the interactions between genetic and epigenetic mechanisms regulating COMT and its influence on...

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Identifiers

PMID: 36284330
DOI: 10.1186/s12967-022-03662-7
PMCID: PMC9598022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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