Article
COMT gene locus: new functional variants.
Pain - 1 Oct 2015
Meloto Carolina B, Segall Samantha K, Smith Shad, Parisien Marc, Shabalina Svetlana A, Rizzatti-Barbosa Célia M, Gauthier Josée, Tsao Douglas, Convertino Marino, Piltonen Marjo H, Slade Gary Dmitri, Fillingim Roger B, Greenspan Joel D, Ohrbach Richard, Knott Charles, Maixner William, Zaykin Dmitri, Dokholyan Nikolay V, Reenilä Ilkka, Männistö Pekka T, Diatchenko Luda
Abstract excerpt
Catechol-O-methyltransferase (COMT) metabolizes catecholaminergic neurotransmitters. Numerous studies have linked COMT to pivotal brain functions such as mood, cognition, response to stress, and pain. Both nociception and risk of clinical pain have been associated with COMT genetic variants, and this association was shown to be mediated through adrenergic pathways. Here, we show that association studies between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.