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Article

Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila.

PLoS genetics - 1 Nov 2009

Ho Margaret C W, Johnsen Holly, Goetz Sara E, Schiller Benjamin J, Bae Esther, Tran Diana A, Shur Andrey S, Allen John M, Rau Christoph, Bender Welcome, Fisher William W, Celniker Susan E, Drewell Robert A

Abstract excerpt

It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint. This belief holds true for the protein-coding homeotic (Hox) genes originally discovered in Drosophila melanogaster. Expression of the Hox genes in Drosophila embryos is essential for body patterning and is controlled by an extensive array of...

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Identifiers

PMID: 19893611
DOI: 10.1371/journal.pgen.1000709
PMCID: PMC2763271

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