Repressor domain and nuclear localization signal of the murine Hoxa-11 protein are located in the homeodomain: no evidence for role of poly alanine stretches in transcriptional repression.

Abstract excerpt

Hoxa-11 is a member of the homeodomain class of transcription factors, which play important roles in metazoan development. Hoxa-11 is particularly interesting because it is involved in a major mammalian innovation, uterus development and gestation. We are interested in the molecular changes underlying this evolutionary innovation. Although phenotypes resulting from loss of functions are well investigated (e.g.,...

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