Article
Genome-wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster.
PloS one - 1 Jan 2012
Jordan Katherine W, Craver Kyle L, Magwire Michael M, Cubilla Carmen E, Mackay Trudy F C, Anholt Robert R H
Abstract excerpt
Reactive oxygen species (ROS) are a common byproduct of mitochondrial energy metabolism, and can also be induced by exogenous sources, including UV light, radiation, and environmental toxins. ROS generation is essential for maintaining homeostasis by triggering cellular signaling pathways and host defense mechanisms. However, an imbalance of ROS induces oxidative stress and cellular death and is associated with...
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