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Article

Characterization of Stress Responses in a Drosophila Model of Werner Syndrome.

Biomolecules - 12 Dec 2021

Epiney Derek G, Salameh Charlotte, Cassidy Deirdre, Zhou Luhan T, Kruithof Joshua, Milutinović Rolan, Andreani Tomas S, Schirmer Aaron E, Bolterstein Elyse

Abstract excerpt

As organisms age, their resistance to stress decreases while their risk of disease increases. This can be shown in patients with Werner syndrome (WS), which is a genetic disease characterized by accelerated aging along with increased risk of cancer and metabolic disease. WS is caused by mutations in WRN, a gene involved in DNA replication and repair. Recent research has shown that WRN mutations contribute to...

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Identifiers

PMID: 34944512
DOI: 10.3390/biom11121868
PMCID: PMC8699552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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