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Article

Differential effects of paraquat-induced oxidative stress on functional aging and lifespan in male and female Drosophila melanogaster.

PloS one - 1 Jan 2026

Fidan Mehmet

Abstract excerpt

Aging is accompanied by loss of motor function driven by mitochondrial oxidative stress. To examine how genotype and sex modulate this process, we exposed Oregon-R (wild-type) and vestigial (wing-deficient) Drosophila of both sexes to chronic paraquat a mitochondrial stressor generating sustained ROS production at 0, 10, or 20 mM. We tracked climbing performance from day 5-50 alongside survival. Paraquat impaired...

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Identifiers

PMID: 41838763
DOI: 10.1371/journal.pone.0336096
PMCID: PMC12991275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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