Article
Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster.
Molecular ecology - 1 May 2021
Lovejoy Pamela C, Foley Kate E, Conti Melissa M, Meadows Samantha M, Bishop Christopher, Fiumera Anthony C
Abstract excerpt
Toxicant resistance is a complex trait, affected both by genetics and the environment. Like most complex traits, it can exhibit sexual dimorphism, yet sex is often overlooked as a factor in studies of toxicant resistance. Paraquat, one such toxicant, is a commonly used herbicide and is known to produce mitochondrial oxidative stress, decrease dopaminergic neurons and dopamine (DA) levels, and decrease motor...
Topics
- Animals
- Drosophila
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Genetic Variation
- Genome-Wide Association Study
- Male
- Paraquat
