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Article

Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.

Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2006

Walker David W, Hájek Petr, Muffat Julien, Knoepfle Dan, Cornelison Stephanie, Attardi Giuseppe, Benzer Seymour

Abstract excerpt

Oxidative stress is implicated as a major cause of aging and age-related diseases, such as Parkinson's and Alzheimer's, as well as ischemia-reperfusion injury in stroke. The mitochondrial electron transport chain is the principal source of reactive oxygen species within cells. Despite considerable medical interest, the molecular mechanisms that regulate reactive oxygen species formation within the mitochondrion...

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Identifiers

PMID: 17056719
DOI: 10.1073/pnas.0607918103
PMCID: PMC1618815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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