Article
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Genes & development - 15 Jun 2012
Chen Shuzhen, Ma Jian, Wu Feizhen, Xiong Li-Jun, Ma Honghui, Xu Wenqi, Lv Ruitu, Li Xiaodong, Villen Judit, Gygi Steven P, Liu Xiaole Shirley, Shi Yang
Abstract excerpt
The histone H3 Lys 27 (H3K27) demethylase JMJD3 has been shown to play important roles in transcriptional regulation and cell differentiation. However, the mechanism underlying JMJD3-mediated transcriptional regulation remains incompletely understood. Here we show that JMJD3 is associated with KIAA1718, whose substrates include dimethylated H3K27 (H3K27me2), and proteins involved in transcriptional elongation....
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