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Article

The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

Molecular and cellular biology - 1 Aug 2005

Cowley Shaun M, Iritani Brian M, Mendrysa Susan M, Xu Tina, Cheng Pei Feng, Yada Jason, Liggitt H Denny, Eisenman Robert N

Abstract excerpt

The corepressor mSin3A is the core component of a chromatin-modifying complex that is recruited by multiple gene-specific transcriptional repressors. In order to understand the role of mSin3A during development, we generated constitutive germ line as well as conditional msin3A deletions. msin3A deletion in the developing mouse embryo results in lethality at the postimplantation stage, demonstrating that it is an...

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Identifiers

PMID: 16055712
DOI: 10.1128/MCB.25.16.6990-7004.2005
PMCID: PMC1190252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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