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JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML

16 Aug 2018

Abstract excerpt

JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. However, how this histone modifier affects in a cell type-dependent manner remains unclear. Here, we show that in contrast to its oncogenic effect in preleukemia state and lymphoid malignancies, JMJD3 relieves the differentiation-arrest of certain subtypes (such as M2 and M3)...

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PMID: 30135572
DOI: 10.1038/s41467-018-05548-z

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