Article

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

2020-02-12

Abstract excerpt

<h4>SUMMARY</h4> The C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) is a regulatory hub for transcription and RNA processing. Here, we identify PHD-finger protein 3 (PHF3) as a new CTD-binding factor that negatively regulates transcription and mRNA stability. The PHF3 SPOC domain preferentially binds to CTD repeats phosphorylated on Serine-2 and PHF3 tracks with Pol II across the len...

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Literature Corpus work: a5bb2f11-3d06-58a9-9f28-f0bbc3e0a846
DOI: 10.1101/2020.02.11.943159

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