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Article

Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS.

Neurobiology of disease - 1 Aug 2020

Bourefis Annis-Rayan, Campanari Maria-Letizia, Buee-Scherrer Valerie, Kabashi Edor

Abstract excerpt

Mutations in Fused in sarcoma (FUS), an RNA-binding protein, are known to cause Amyotrophic Lateral Sclerosis (ALS). However, molecular mechanisms due to loss of FUS function remain unclear and controversial. Here, we report the characterization and phenotypic analysis of a deletion mutant of the unique FUS orthologue in zebrafish where Fus protein levels are depleted. The homozygous mutants displayed a reduced...

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Identifiers

PMID: 32380281
DOI: 10.1016/j.nbd.2020.104935

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