Article
Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease.
Human genetics - 1 Mar 2021
Thompson Brian, Davidson Emily A, Liu Wei, Nebert Daniel W, Bruford Elspeth A, Zhao Hongyu, Dermitzakis Emmanouil T, Thompson David C, Vasiliou Vasilis
Abstract excerpt
Paired-box (PAX) genes encode a family of highly conserved transcription factors found in vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain that is evolutionarily conserved across phylogenies. Inclusion of a homeodomain and/or an octapeptide linker subdivides PAX proteins into four groups. Often termed "master regulators", PAX proteins orchestrate tissue and organ...
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