Article
NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia.
Nature communications - 2 Oct 2017
Märklin Melanie, Heitmann Jonas S, Fuchs Alexander R, Truckenmüller Felicia M, Gutknecht Michael, Bugl Stefanie, Saur Sebastian J, Lazarus Juliane, Kohlhofer Ursula, Quintanilla-Martinez Leticia, Rammensee Hans-Georg, Salih Helmut R, Kopp Hans-Georg, Haap Michael, Kirschniak Andreas, Kanz Lothar, Rao Anjana, Wirths Stefan, Müller Martin R
Abstract excerpt
Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells. Most patients are characterised by an indolent disease course and an anergic phenotype of their leukaemia cells, which refers to a state of unresponsiveness to B cell receptor stimulation. Up to 10% of CLL patients transform from an indolent subtype to an aggressive form of B cell lymphoma over time (Richter´s syndrome) and show a...
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