Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

doi:10.1038/sj.onc.1201089

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Article

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

Oncogene - 29 May 1997

Acton D, Jacobs H, Domen J, Berns A

Abstract excerpt

Overexpression of the bcl-2 oncogene in the lymphoid compartment of transgenic mice prolongs the lifespan of lymphocytes and leads to a low incidence of lymphomas at later age. Transgenic mice carrying a mutated T-cell receptor lacking the variable domain (deltaV-TCRbeta) suffer from lymphocyte d...

Topics

Animals
Antigens, CD
B-Lymphocytes
Cell Survival
Concanavalin A
Crosses, Genetic
Female
Interleukin-7
Lipopolysaccharides
Lymphoma
Macrophage Colony-Stimulating Factor
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Transgenic
Phenotype
Proto-Oncogene Proteins c-bcl-2

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