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Article

Bcl-2 reduces lymphomagenesis in deltaV-TCRbeta transgenic mice.

Oncogene - 29 May 1997

Acton D, Jacobs H, Domen J, Berns A

Abstract excerpt

Overexpression of the bcl-2 oncogene in the lymphoid compartment of transgenic mice prolongs the lifespan of lymphocytes and leads to a low incidence of lymphomas at later age. Transgenic mice carrying a mutated T-cell receptor lacking the variable domain (deltaV-TCRbeta) suffer from lymphocyte depletion and are highly predisposed to lymphoma development. We intercrossed Bcl-2-Ig and deltaV-TCRbeta transgenic...

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Identifiers

PMID: 9191049
DOI: 10.1038/sj.onc.1201089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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