Article
Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.
Molecular psychiatry - 1 May 2013
Vélez J I, Chandrasekharappa S C, Henao E, Martinez A F, Harper U, Jones M, Solomon B D, Lopez L, Garcia G, Aguirre-Acevedo D C, Acosta-Baena N, Correa J C, Lopera-Gómez C M, Jaramillo-Elorza M C, Rivera D, Kosik K S, Schork N J, Swanson J M, Lopera F, Arcos-Burgos M
Abstract excerpt
The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such large cohorts, we describe here a novel sequential strategy that combines pooling of DNA and...
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