Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Menin and p53 have non-synergistic effects on tumorigenesis in mice.

BMC cancer - 18 Jun 2012

Loffler Kelly A, Mould Arne W, Waring Paul M, Hayward Nicholas K, Kay Graham F

Abstract excerpt

BACKGROUND: While it is now more than a decade since the first description of the gene mutation underlying the tumour predisposition syndrome multiple endocrine neoplasia type 1 (MEN1), the mechanism by which its protein product menin acts to prevent development of tumours is still poorly understood. METHODS: We undertook a genetic experiment to assess whether menin synergises with p53. Mice carrying various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Glands
Share to Body Weight
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Multiple Endocrine Neoplasia Type 1

Share to Neoplasms

Share to Pancreas

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 22708734
DOI: 10.1186/1471-2407-12-252
PMCID: PMC3433377

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Menin and p53 have non-synergistic effects on tumorigenesis in mice.PMID 22708734Read ↗

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1Semantic proximity Read ↗

Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Lack of augmentation of tumor spectrum or severity in dual heterozygous Men1 and Rb1 knockout mice.Semantic proximity Read ↗

Kmt2acooperates with menin to suppress tumorigenesis in mouse pancreatic isletsSemantic proximity Read ↗

High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands.Semantic proximity Read ↗

MENIN loss as a tissue-specific driver of tumorigenesis.Semantic proximity Read ↗

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsSemantic proximity Read ↗

Conditional Inactivation of the <i>Men1</i> Gene Leads to Pancreatic and Pituitary Tumorigenesis but Does Not Affect Normal Development of These TissuesSemantic proximity Read ↗

Cell lineage-specific interactions between Men1 and Rb in neuroendocrine neoplasia.Semantic proximity Read ↗

Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.Semantic proximity Read ↗

Menin Molecular Interactions: Insights into Normal Functions and TumorigenesisSemantic proximity Read ↗

Characterisation of prostate cancer lesions in heterozygous Men1 mutant miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.