Article
Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2003
Bertolino Philippe, Tong Wei-Min, Galendo Dominique, Wang Zhao-Qi, Zhang Chang-Xian
Abstract excerpt
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome characterized by the occurrence of multiple endocrine tumors of the parathyroid, pancreas, and anterior pituitary in patients. To study tumorigenesis related to the MEN1 syndrome, we have generated Men1 knockout mice using the ge...
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