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Article

Characterisation of prostate cancer lesions in heterozygous Men1 mutant mice

27 Jul 2010

Abstract excerpt

BACKGROUND: Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology. Intriguingly, rare lesions in hormone-dependent tissues, such as prostate and mammary glands, were also observed in the Men1 mutant mice. METHODS: To study the occurrence of prostate lesions, we followed a male mouse...

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PMID: 20663219
DOI: 10.1186/1471-2407-10-395

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