Article
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.
Mechanisms of development - 1 May 2003
Bertolino Philippe, Radovanovic Ivan, Casse Huguette, Aguzzi Adriano, Wang Zhao-Qi, Zhang Chang-Xian
Abstract excerpt
Patients suffering from multiple endocrine neoplasia type 1 (MEN1) are predisposed to multiple endocrine tumors. The MEN1 gene product, menin, is expressed in many embryonic, as well as adult tissues, and interacts with several proteins in vitro and in vivo. However, the biological function of menin remains largely unknown. Here we show that disruption of the Men1 gene in mice causes embryonic lethality at...
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