Article
MENIN loss as a tissue-specific driver of tumorigenesis.
Molecular and cellular endocrinology - 5 Jul 2018
Li Janet W Y, Hua Xianxin, Reidy-Lagunes Diane, Untch Brian R
Abstract excerpt
The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities...
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