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Article

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Baker Rosanna P, Young Keith, Feng Liang, Shi Yigong, Urban Sinisa

Abstract excerpt

Intramembrane proteolysis is a core regulatory mechanism of cells that raises a biochemical paradox of how hydrolysis of peptide bonds is accomplished within the normally hydrophobic environment of the membrane. Recent high-resolution crystal structures have revealed that rhomboid proteases contain a catalytic serine recessed into the plane of the membrane, within a hydrophilic cavity that opens to the...

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Identifiers

PMID: 17463085
DOI: 10.1073/pnas.0700814104
PMCID: PMC1895938

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