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Article

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells.

Biological chemistry - 1 Aug 2008

Urban Sinisa, Baker Rosanna P

Abstract excerpt

Intramembrane proteases hydrolyze peptide bonds within cell membranes. Recent crystal structures revealed that rhomboid intramembrane proteases contain a hydrated active site that opens to the outside of the cell, but is protected laterally from membrane lipids by protein segments. Using Escheric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18979634
DOI: 10.1515/BC.2008.122
PMCID: PMC2678756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18979634-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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