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Article

The structural basis for catalysis and substrate specificity of a rhomboid protease.

The EMBO journal - 17 Nov 2010

Vinothkumar Kutti R, Strisovsky Kvido, Andreeva Antonina, Christova Yonka, Verhelst Steven, Freeman Matthew

Abstract excerpt

Rhomboids are intramembrane proteases that use a catalytic dyad of serine and histidine for proteolysis. They are conserved in both prokaryotes and eukaryotes and regulate cellular processes as diverse as intercellular signalling, parasitic invasion of host cells, and mitochondrial morphology. Their widespread biological significance and consequent medical potential provides a strong incentive to understand the...

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Identifiers

PMID: 20890268
DOI: 10.1038/emboj.2010.243
PMCID: PMC2989101

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