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Article

Molecular analysis of hprt mutants induced by 2-cyanoethylene oxide in human lymphoblastoid cells.

Mutation research - 1 Nov 1990

Recio L, Simpson D, Cochrane J, Liber H, Skopek T R

Abstract excerpt

The mutagenic epoxide metabolite of acrylonitrile, 2-cyanoethylene oxide (ANO), was used to treat human TK6 lymphoblasts (150 microM x 2 h ANO). A collection of hypoxanthine-phosphoribosyltransferase (hprt) mutants was isolated and characterized by dideoxy sequencing of cloned hprt cDNA. Base-pair substitution mutations in the hprt coding region were observed in 19/39 of hprt mutants: 11 occurred at AT base pairs...

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Identifiers

PMID: 2270092
DOI: 10.1016/0165-1218(90)90085-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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