Molecular analysis of ethylene oxide-induced mutations at the HPRT locus in human diploid fibroblasts.

doi:10.1016/0027-5107(93)90021-7

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Article

Molecular analysis of ethylene oxide-induced mutations at the HPRT locus in human diploid fibroblasts.

Mutation research - 1 Jun 1993

Bastlová T, Andersson B, Lambert B, Kolman A

Abstract excerpt

Ethylene oxide (EtO)-induced mutations in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene were characterized in 28 independently derived 6-thioguanine-resistant human diploid fibroblast clones using polymerase chain reaction-based techniques and Southern blot analysis. Sequence ana...

Topics

Base Sequence
Cell Line
Ethylene Oxide
Fibroblasts
Humans
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation

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