Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2012

Araki Tsuyoshi, Kawata Takefumi, Williams Jeffrey G

Abstract excerpt

SH2 domains are integral to many animal signaling pathways. By interacting with specific phosphotyrosine residues, they provide regulatable protein-protein interaction domains. Dictyostelium is the only nonmetazoan with functionally characterized SH2 domains, but the cognate tyrosine kinases are unknown. There are no orthologs of the animal tyrosine kinases, but there are very many tyrosine kinase-like kinases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dictyostelium
Share to Focal Adhesion Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Mapping

Share to Protein-Tyrosine Kinases

Share to Protozoan Proteins

Share to src Homology Domains

Share to STAT Transcription Factors

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 22699506
DOI: 10.1073/pnas.1202715109
PMCID: PMC3396520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling.PMID 22699506Read ↗

Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development.Semantic proximity Read ↗

Transcription co-activator SAYP mediates the action of STAT activator.Semantic proximity Read ↗

A Road Map for Those Who Don't Know JAK-STATSemantic proximity Read ↗

Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.Semantic proximity Read ↗

C. elegans STAT: evolution of a regulatory switch.Semantic proximity Read ↗

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity.Semantic proximity Read ↗

Phylogeny of Tec family kinases identification of a premetazoan origin of Btk, Bmx, Itk, Tec, Txk, and the Btk regulator SH3BP5.Semantic proximity Read ↗

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.Semantic proximity Read ↗

A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling.Semantic proximity Read ↗

Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.Semantic proximity Read ↗

Mechanism of activation of an ancestral TEC kinase by PIP <sub>3</sub>Semantic proximity Read ↗

Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.