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Article

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.

Developmental biology - 15 May 2011

Sugden Christopher, Ross Susan, Annesley Sarah J, Cole Christian, Bloomfield Gareth, Ivens Alasdair, Skelton Jason, Fisher Paul R, Barton Geoffrey, Williams Jeffrey G

Abstract excerpt

Dictyostelium is the only non-metazoan with functionally analyzed SH2 domains and studying them can give insights into their evolution and wider potential. LrrB has a novel domain configuration with leucine-rich repeat, 14-3-3 and SH2 protein-protein interaction modules. It is required for the correct expression of several specific genes in early development and here we characterize its role in later,...

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Identifiers

PMID: 21396932
DOI: 10.1016/j.ydbio.2011.03.003
PMCID: PMC3085826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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