A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.

doi:10.1016/j.ydbio.2011.03.003

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Article

A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation.

Developmental biology - 15 May 2011

Sugden Christopher, Ross Susan, Annesley Sarah J, Cole Christian, Bloomfield Gareth, Ivens Alasdair, Skelton Jason, Fisher Paul R, Barton Geoffrey, Williams Jeffrey G

Abstract excerpt

Dictyostelium is the only non-metazoan with functionally analyzed SH2 domains and studying them can give insights into their evolution and wider potential. LrrB has a novel domain configuration with leucine-rich repeat, 14-3-3 and SH2 protein-protein interaction modules. It is required for the correct expression of several specific genes in early development and here we characterize its role in later,...

Topics

Base Sequence
DNA Primers
DNA, Protozoan
Darkness
Dictyostelium
Extracellular Matrix Proteins
Gene Expression Profiling
Gene Expression Regulation, Developmental
Genes, Protozoan
Hexanones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Metalloendopeptidases

Mutation

Oligonucleotide Array Sequence Analysis

Polymerase Chain Reaction

Protozoan Proteins

Signal Transduction

src Homology Domains

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Identifiers

PMID: 21396932
DOI: 10.1016/j.ydbio.2011.03.003
PMCID: PMC3085826

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