Article
Transcription co-activator SAYP mediates the action of STAT activator.
Nucleic acids research - 1 Mar 2012
Panov Vladislav V, Kuzmina Julia L, Doronin Semen A, Kopantseva Marina R, Nabirochkina Elena N, Georgieva Sofia G, Vorobyeva Nadezhda E, Shidlovskii Yulii V
Abstract excerpt
Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven...
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