Article
C. elegans STAT: evolution of a regulatory switch.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2006
Wang Yaming, Levy David E
Abstract excerpt
STAT transcription factors have been implicated in many biological processes, particularly host immune defense and development. Here we characterize a STAT orthologue from the nematode, C. elegans. We show that this protein, termed STA-1, is structurally and functionally related to other vertebrate and invertebrate STAT proteins, recognizing a cis DNA element conserved through phylogeny. Unexpectedly, STA-1 lacks...
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