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Article

The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2012

Hamilton Gillian, Harris Sarah E, Davies Gail, Liewald David C, Tenesa Albert, Payton Antony, Horan Michael A, Ollier William E R, Pendleton Neil, Starr John M, Porteous David, Deary Ian J

Abstract excerpt

The β-amyloid peptide may play a central role in Alzheimer's disease (AD) pathogenesis. We have evaluated variants in seven Aβ-degrading genes (ACE, ECE1, ECE2, IDE, MME, PLAU, and TF) for association with AD risk in the Genetic and Environmental Risk in Alzheimer's Disease Consortium 1 (GERAD1) cohort, and with three cognitive phenotypes in the Lothian Birth Cohort 1936 (LBC1936), using 128 and 121 SNPs,...

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Source

Identifiers

PMID: 22693153
DOI: 10.1002/ajmg.b.32073

Genes

ECE1
APOE
ACE
ECE2
IDE
MME
PLAU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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