Article
Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.
Journal of Alzheimer's disease : JAD - 1 Apr 2008
Bekris Lynn M, Millard Steven P, Galloway Nichole M, Vuletic Simona, Albers John J, Li Ge, Galasko Douglas R, DeCarli Charles, Farlow Martin R, Clark Chris M, Quinn Joseph F, Kaye Jeffrey A, Schellenberg Gerard D, Tsuang Debby, Peskind Elaine R, Yu Chang-En
Abstract excerpt
The epsilon4 allele of the apolipoprotein E gene (APOE) is associated with increased risk and earlier age at onset in late onset Alzheimer's disease (AD). Other factors, such as expression level of apolipoprotein E protein (apoE), have been postulated to modify the APOE related risk of developing AD. Multiple loci in and outside of APOE are associated with a high risk of AD. The aim of this exploratory hypothesis...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- DNA Primers
- Enhancer Elements, Genetic
- Female