Article
Sex Differences in Cognitive Abilities Among Children With the Autosomal Dominant Alzheimer Disease Presenilin 1 E280A Variant From a Colombian Cohort.
JAMA network open - 2 Aug 2021
Fox-Fuller Joshua T, Artola Arabiye, Chen Kewei, Pulsifer Margaret, Ramirez Dora, Londono Natalia, Aguirre-Acevedo Daniel C, Vila-Castelar Clara, Baena Ana, Martinez Jairo, Arboleda-Velasquez Joseph F, Langbaum Jessica B, Tariot Pierre N, Reiman Eric M, Lopera Francisco, Quiroz Yakeel T
Abstract excerpt
Importance: We previously reported that children with the autosomal dominant Alzheimer disease (ADAD) presenilin 1 (PSEN1) E280A variant had early life plasma biomarker findings consistent with amyloid β overproduction. However, the cognitive functioning of children with this variant has not been characterized vs those without the variant. Objective: To test whether cognitive functioning of children with and...
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