Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.

Journal of neurology - 1 Aug 2003

Clarimón Jordi, Bertranpetit Jaume, Calafell Francesc, Boada Mercè, Tàrraga Lluís, Comas David

Abstract excerpt

BACKGROUND: Amyloid beta-peptide (Abeta) biosynthesis, aggregation and degradation constitute three important steps to consider in the study of pathological mechanisms involved in Alzheimer's disease (AD). Several proteins have been suggested as involved in each of these processes: proteolytic cl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Alu Elements
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Amyloid Precursor Protein Secretases

Share to Aspartic Acid Endopeptidases

Share to Endopeptidases

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 12928915
DOI: 10.1007/s00415-003-1127-8

Genes

BACE1
ACHE
APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12928915-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association study between Alzheimer's disease and genes involved in Abeta biosynthesis, aggregation and degradation: suggestive results with BACE1.PMID 12928915Read ↗

Relationship between the polymorphism in exon 5 of BACE1 gene and Alzheimer's disease.Semantic proximity Read ↗

Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations: meta-analysis including Korean samples.Semantic proximity Read ↗

Polymorphism in the BACE gene influences the risk for Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease.Semantic proximity Read ↗

Meta-analysis of BACE1 gene rs638405 polymorphism and the risk of Alzheimer's disease in Caucasion and Asian population.Semantic proximity Read ↗

Association studies using novel polymorphisms in BACE1 and BACE2.Semantic proximity Read ↗

The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer's disease in Chinese Hans.Semantic proximity Read ↗

Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s DiseaseSemantic proximity Read ↗

BACE1 gene promoter single-nucleotide polymorphisms in Alzheimer's disease.Semantic proximity Read ↗

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.Semantic proximity Read ↗

Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers.Semantic proximity Read ↗

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-CarriersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.