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Article

APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Peuralinna Terhi, Tanskanen Maarit, Mäkelä Mira, Polvikoski Tuomo, Paetau Anders, Kalimo Hannu, Sulkava Raimo, Hardy John, Lai Shiao-Lin, Arepalli Sampath, Hernandez Dena, Traynor Bryan J, Singleton Andrew, Tienari Pentti J, Myllykangas Liisa

Abstract excerpt

Cortical and cerebrovascular amyloid-β (Aβ) deposition is a hallmark of Alzheimer's disease (AD), but also occurs in elderly people not affected by dementia. The apolipoprotein E (APOE) ε4 is a major genetic modulator of Aβ deposition and AD risk. Variants of the amyloid-β protein precursor (AβPP) gene have been reported to contribute to AD and cerebral amyloid angiopathy (CAA). We analyzed the role of APOE and...

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Identifiers

PMID: 21654062
DOI: 10.3233/JAD-2011-102049
PMCID: PMC3516850

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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