Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs.

Behavioral and brain functions : BBF - 12 Jun 2012

Docherty Sophia J, Davis Oliver Sp, Haworth Claire Ma, Plomin Robert, D'Souza Ursula, Mill Jonathan

Abstract excerpt

BACKGROUND: Dopamine receptor D4(DRD4) polymorphisms have been associated with a number of psychiatric disorders, but little is known about the mechanism of these associations. DNA methylation is linked to the regulation of gene expression and plays a vital role in normal cellular function, with abnormal DNA methylation patterns implicated in a range of disorders. Recent evidence suggests DNA methylation can be...

Topics

Alzheimer Disease
DNA Methylation
Female
Gene Expression
Genetic Association Studies
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Receptors, Dopamine D4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 22691691
DOI: 10.1186/1744-9081-8-31
PMCID: PMC3538530

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22691691-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs.PMID 22691691Read ↗

Epigenetic regulation of the DRD4 gene and dimensions of attention-deficit/hyperactivity disorder in children.Semantic proximity Read ↗

Analysis of association between dopamine receptor genes' methylation and their expression profile with the risk of schizophrenia.Semantic proximity Read ↗

Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males.Semantic proximity Read ↗

Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder.Semantic proximity Read ↗

Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4).Semantic proximity Read ↗

Methylation quantitative locus rs3758653 in the DRD4 gene is associated with duration from first heroin exposure to addiction.Semantic proximity Read ↗

DNA methylation associated with persistent ADHD suggests TARBP1 as novel candidateSemantic proximity Read ↗

Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene.Semantic proximity Read ↗

DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.Semantic proximity Read ↗

Hypermethylation and increased expression of the DRD2 gene in schizophrenia.Semantic proximity Read ↗

Low methylation rates of dopamine receptor D2 gene promoter sites in Japanese schizophrenia subjects.Semantic proximity Read ↗

The DRD4 receptor Exon 3 VNTR and 5' SNP variants and mRNA expression in human post-mortem brain tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.