Article
The DRD4 receptor Exon 3 VNTR and 5' SNP variants and mRNA expression in human post-mortem brain tissue.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2010
Simpson Jennifer, Vetuz Glenn, Wilson Mathew, Brookes Keeley J, Kent Lindsey
Abstract excerpt
Genetic variation within the dopamine D4 receptor (DRD4) gene has been implicated in many neuropsychiatric disorders and behavioral traits. This variation includes the extensively studied exon 3 variably numbered tandem repeat (VNTR), and several 5' polymorphisms including a120-bp duplication and two single-nucleotide polymorphisms at -521 C/T (rs1800955) and -616 C/G (rs747302). Several reports have provided...
Topics
- Adolescent
- Adult
- Aged
- Autopsy
- Brain
- Exons
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Minisatellite Repeats
- Polymorphism, Single Nucleotide
- RNA, Messenger
- Receptors, Dopamine D4
- Young Adult