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Article

Hypermethylation and increased expression of the DRD2 gene in schizophrenia.

BMC psychiatry - 15 Jul 2025

Qing Lili, Zou Tiantian, Yin Wensa, Wu Run, Cheng Tiantian, Yuan Haodi, Zhou Chen, Chen Xuanyu, Wang Jia, Yang Ting, Hu Liping, Liu Linlin, Nie Shengjie

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) is one of the most serious mental disorders, and dysfunction of the dopamine system is a key pathological hypothesis for SCZ. The DRD2 gene is a risk gene for SCZ, and its methylation is also considered an important marker of SCZ. Among methylation sites of A total of 21 CpG sites were detected2, the CpG island upstream of exon 1 has been the most commonly studied. To our...

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PMID: 40665271
DOI: 10.1186/s12888-025-07154-y
PMCID: PMC12265376

Genes

DRD2

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