Article
Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males.
Molecular medicine reports - 1 Sept 2016
Ji Huihui, Wang Yunliang, Jiang Danjie, Liu Guili, Xu Xuting, Dai Dongjun, Zhou Xiaohui, Cui Wei, Li Jinfeng, Chen Zhongming, Li Ying, Zhou Dongsheng, Zha Qin, Zhuo Renjie, Jiang Liting, Liu Yu, Shen Lili, Zhang Beibei, Xu Lei, Hu Haochang, Zhang Yuzheng, Yin Honglei, Duan Shiwei, Wang Qinwen
Abstract excerpt
Aberrant promoter methylation of multiple genes is associated with various diseases, including Alzheimer's disease (AD). The goal of the present study was to determine whether dopamine receptor D4 (DRD4) promoter methylation is associated with AD. In the current study, the methylation levels of the DRD4 promoter were measured in 46 AD patients and 61 controls using bisulfite pyrosequencing technology. The results...
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